Group Leader, Cellular Signaling Assays NIH Chemical Genomics Center Education Ph.D. in Biochemical Pharmacology, SUNY at Buffalo, NY Contact ncgc@wzheng.nih.gov

Prior to joining the NIH Chemical Genomics Center, Dr. Zheng was a Senior Research Fellow at Merck & Co.

Recent Publications:

• Zheng W, Padia J, Urban DJ, Jadhav A, Goker-Alpan O, Simeonov A, Goldin E, Auld D, LaMarca ME, Inglese J,Austin CP, Sidransky E. Three novel structural classes of glucocerebrosidase inhibitors identified by qHTS as chemical chaperone leads for Gaucher disease. Proc Natl Acad Sci USA, in press.
• IngleseJ, Johnson RL, Simeonov A, Xia M, Zheng W, Austin CP and Auld DS. High Throughput Screening Assays for the Investigation of Chemical Biology. Manuscript accepted by Nat Chem Biol (2007).
• Auld DS, Johnson RL, Zhang Y, Veith H, Jadhav A, Yasgar A, Simeonov A, Zheng W, Martinez ED, Westwick JK, Austin CP, Inglese J (2006). Fluorescent protein-based cellular assays analyzed by laser scanning microplate cytometry in 1536-well plate format. Methods in Enzymology, Measuring Biological Responses with Automated Microscopy 414: 566-589.
• Inglese J, Auld DS, Jadhav A, Johnson RL, Simeonov A, Yasgar A, Zheng W, Austin CP (2006). Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc Natl Acad Sci USA 103:11473-11478.
• Brandish PE, Chiu CS, Schneeweis J, Brandon NJ, Leech CL, Kornienko O, Scolnick EM, Strulovici B and Zheng W (2006). A Cell-based Ultra-High Throughput Screening Assay for Identifying Inhibitors of D-Amino Acid Oxidase. J Biomol Screen 11: 481-487.
• Kunapuli P, Lee S, Zheng W, Alberts M, Kornienko O, Mull R, Kreamer A, Hwang JI, Simon MI, Strulovici B. Identification of small molecule antagonists of the human mas-related gene (MRG)-X1 receptor. Anal Biochem 351: 50-61. (2006)
• Triggle DJ, Gopalakrishnan M, Rampe D, Zheng W (editors). Voltage-Gated Ion Channels as Drug Targets. Methods and Principles in Medicinal Chemistry. Wiley-Vch. Vol. 29 (2006).
• Zheng W, Brandish P. Scintillation Proximity Assay of Inositol Phosphates. In Handbook of Assay Development in Drug Discovery. Minor LK (editor), CRC Press, part of Taylor & Francis (2006).
• Solly K, Mundt SS, Zokian HJ, Ding GJ, Hermanowski-Vosatka A, Strulovici B, Zheng W. High Throughput Screening of 11a-Hydroxysteroid Dehydrogenase Type 1 in Scintillation Proximity Assay Format. Assay Drug Dev Technol. 3: 377-384 (2005).
• Kunapuli P, Zheng W, Weber M, Solly K, Mull R, Platchek M, Cong M, Zhong Z, Strulovici B. Application of division arrest technology to cell-based HTS: comparison with frozen and fresh cells. Assay Drug Dev Technol. 3:17-26 (2005).
• Zheng W, Brandish PE, Kolodin DG, Scolnick EM, Strulovici B. High Throughput Cell-Based Screening Using Scintillation Proximity Assay for the Discovery of Inositol Phosphatase Inhibitors. J Biomol Scr. 9:132-140 (2004)
• Zheng W, Spencer RH, Kiss L. High throughput assay technologies for ion channel drug discovery. Assay Drug Dev Technol. 2:543-52 (2004).

• Application of Quantitative HTS for Accelerating Hit-to-Lead Process in Discovery of Glucocerebrosidase Inhibitors. In “the 223rd American Chemical Society National meeting”, on March 28th, 2007, Chicago, Illinois
• NIH Chemical Genomics Center and New Wave of Probe Discovery in Academia. In the Drug Discovery for Ion Channels VII Satellite Meeting at the Annual Biophysical Society Meeting, March 2nd, 2007, Baltimore, MD
• A Practical Approach for Robotic Screening of Cell-Based Assay. In “12th Annual Conference of Society for Biomolecular Sciences”, September 17-21, 2006, Seattle, WA
• Accelerating Hit to Lead Discovery with a qHTS Approach. In PharmaIQ’s “Hit to Lead 2006 Conference”, July 13 - 14, 2006. In Amsterdam, Netherlands
• session Chair for Technology/Assay Comparison. Presentation: Quantitative HTS – A New Screening Platform for Lead Discovery. In IBC’s “ScreeTech 2006”, March 22-24, 2006, San Diego, CA
• session Co-chair for Comparing HTS Technologies. Presentation: Application of High Throughput Screening Technology for Identifying Molecular Probes. In “11th Annual Conference of Society for Biomolecular Screening”, September 11-15, 2005, Geneva, Switzerland.
• NIH Chemicals Genomics Center and HTS Technologies. In “3rd Annual Ion Channel Conference and Retreat”, June 6-8th, 2005, Vancouver, Canada.
• session Chair for Introduction to High Throughput Screening. Presentation: HTS – Current Status and Future Perspectives. In “ScreenTech 2005”, March 21-23, 2005, San Diego, CA
• Applying Cell-Based Enzyme Assays for Discovery of High Quality Leads. In “Tissue Models for Drug Discovery - Engineering the in vitro Environment for More Realistic Physiological Studies”, November 8-9, 2004, Boston, MA
• Early Drug Discovery - from Biochemical Assay to Cell-based Screening and Future Perspectives. In the Workshop of Multimodality Biomedical Systems, NIH, October 22, 2004. Bethesda, MD
• High Throughput Screening Assays for Identifying Inhibitors and Activators of Kinase Targets. In the Workshop of Drug Screening for Ataxia-Telangiectasia. NIH, October 8, 2004, Bethesda, MD.
• Application of a Label-Free Detection Technology to Cell-Based Assays. In “ScreenTech 2004”, on March 21-24, 2004, San Diego, CA.