Informatics Scientist NIH Chemical Genomics Center Contact huangru@mail.nih.gov

Recent Publications:

• Huang, R. et al. Targeting changes in cancer: assessing pathway stability by comparing pathway gene expression coherence levels in tumor and normal tissues. Mol Cancer Ther. 2006 Sep;5(9):2417-27.
• Huang, R. et al. Assessment of in vitro and in vivo activities in the National Cancer Institute's anticancer screen with respect to chemical structure, target specificity, and mechanism of action. J Med Chem. 2006 Mar 23;49(6):1964-79.
• Wallqvist, A. et al. Evaluating chemical structure similarity as an indicator of cellular growth inhibition. J Chem Inf Model. 2006 Jan-Feb;46(1):430-7.
• Huang, R. et al. Comprehensive analysis of pathway or functionally related gene expression in the National Cancer Institute's anticancer screen. Genomics. 2006 Mar;87(3):315-28. Epub 2006 Jan 4.
• Wallqvist, A. et al. Drugs aimed at targeting characteristic karyotypic phenotypes of cancer cells. Mol Cancer Ther. 2005 Oct;4(10):1559-68.
• Covell, DG. et al. Linking tumor cell cytotoxicity to mechanism of drug action: an integrated analysis of gene expression, small-molecule screening and structural databases. Proteins. 2005 May 15;59(3):403-33.
• Huang, R. et al. Anticancer metal compounds in NCI's tumor-screening database: putative mode of action. Biochem Pharmacol. 2005 Apr 1;69(7):1009-39.