NIH Cehmical Genomics Center
National Human Genome Research Institute
National Institutes of Health
Department of Health and Human Services
Position:
Charcot-Marie-Tooth Association (CMTA) Post-doctoral Fellowship at the NCGC
Term:
Two (2) years. Extendable from three (3) to five (5) years.
Background:
Charcot Marie Tooth Disease (CMT) is a heterogeneous group of
genetic disorders that disupt the peripheral nervous system (PNS)
of 1:2500 people of all backgrounds. CMT1A is the most frequent
form, a demyelinating neuropathy caused by over-expression of the
peripheral myelin protein 22 (PMP22) gene and its protein. The
goals of the STAR initiative of the Charcot Marie Tooth Association
(CMTA) are to identify medications that reduce PMP22 expression
and treat patients with CMT1A. The NCGC is an ultrahighthroughput
screening and chemistry center which discovers
chemical probes of protein and cell functions, develops new
paradigms to enable chemical genomics, and develops chemical
starting points for new drugs for rare genetic and orphan diseases.
Located 10 minutes north of the NIH Campus in Rockville, MD, the
Center has a staff of over 60 biologists, chemists, engineers, and
informatics scientists, who work with investigators throughout NIH
and the world to translate the genome into biological function and
therapeutics.
Job Description:
The post-doctoral fellow will be responsible for development and
performance of compound library screening efforts in Charcot-
Marie-Tooth inherited peripheral neuropathy. Successful
candidates should have experience with cell culture and reporter
gene systems, an aptitude for instrumentation, and possess
excellent analytical skills. Responsibilities will include:
- Interact with CMTA investigators to identify potential assays and methodologies that detect CMT phenotypes.
- Develop and optimize cell-based and biochemical assays targeting CMT-based inherited peripheral neuropathy biology.
- Work together with engineers to implement automated highthroughput screens on state-of-the art robotic systems.
- Validate active compounds with secondary assays.
- Interact with chemists and informatics scientists to aid molecular probe development.
- Contribute to the writing of scientific manuscripts for publication, grants to support the CMTA screening program, and progress reports for the CMTA
Contact:
Applicants should send their CV including bibliography, and
arrange for three letters of reference to be sent to James Inglese,
Ph.D., Deputy Director, NIH Chemical Genomics Center, to
NCGC@mail.nih.gov. Subject line should read: CMTA Post-Doc.
Applicants who cannot submit their materials electronically should submit their applications to:
James Inglese
NIH Chemical Genomics Center
National Institutes of Health
9800 Medical Center Drive
Bethesda, MD 20892-3370
NCGC@mail.nih.gov
For more information on the NCGC, see ncgc.nih.gov
For more information on NHGRI, see: genome.gov
For more information on the CMTA, go to harcot-marie-tooth.org
DHHS and NIH are Equal Opportunity Employers
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