Department of Health and Human Services
National Institutes of Health
National Human Genome Research Institute
The NIH Chemical Genomics Center (NCGC) is a new facility within the National
Human Genome Research Institute and is the first in a network of screening
centers being developed as part of the NIH Roadmap for Medical Research (see
NIH Gears Up for Chemical Genomics, Science, June 18, 2004 and
Molecular Libraries Screening Centers Network
). The NCGC will use the tools of small molecule screening and discovery to
develop chemical probes for use in the study of protein and cell functions, and
biological processes relevant to physiology and disease. The Center will
perform automated high-throughput screening (HTS) on biological assays
submitted by the biomedical research community, carry out chemistry
optimization on confirmed hits to produce chemical probes, and disseminate the
data and probes via PubChem, a new division of the National Center for
Biotechnology Information (NCBI). The NCGC Informatics Division will create and
operate a state-of-the-art informatics support and research platform, and apply
these tools to the discovery and characterization of the chemical probes. The
data intensive nature of the effort will require an informatics group capable
of handling large volumes of data obtained from production screening, as well
as addressing the needs of individual researchers in the analysis of data from
all stages of assay optimization and probe discovery. In addition, the group
will coordinate data storage and mining with NCBI and the informatics groups of
the other screening centers.
We are seeking highly qualified candidates to join the NCGC Informatics
Division in three areas: IS/IT, screening informatics (screening data
processing, collection, and analysis), and research computational chemistry.
The NCGC will be a unique and exciting environment employing technologies on
the cutting edge of small molecule screening and chemical genomics.
Candidates will perform one or more of the following duties:
-
Design, build and maintain a robust and flexible informatics infrastructure to
support data collection from automated high-throughput screens
-
Build and maintain databases for chemical compound registration, tracking, and
management
-
Design, maintain, and integrate LIMS
-
Work with biologists and chemists in the Center to analyze data from assays and
screens
-
Perform virtual screening and molecular modeling
-
Analyze data across assays and screening centers, including larger data sets in
PubChem
Requirements:
-
BA/BS, MS, PhD, or equivalent degree
-
Informatics experience in the pharmaceutical or biotech industry, specifically
in the management of databases and automated HTS systems a plus
-
Extensive experience with one or more programming languages
-
Highly motivated, able to wear many hats, and comfortable seeking solutions to
unanticipated problems
-
Demonstrated ability to quickly learn on the job and openness to new ideas and
solutions
-
Must take hands-on approach in meeting informatics/IT needs
-
Strong skills in database design
-
Willing to be a leader in developing new informatics solutions for novel data
types
Interested applicants should send a resume and three letters of recommendation
through our online
application system
.
Applicants who cannot submit their materials electronically should submit
their applications to:
NIH Chemical Genomics Center
National Human Genome Research Institute
50 South Drive
Building 50, Room 5345
Bethesda, MD 20892-8004
NCGC@mail.nih.gov
Applications will be reviewed beginning September 1, 2004 and continue until
positions are filled.
For more information on the NCGC and NHGRI's Intramural Program:
For more information on the NIH Roadmap for Medical Research:
For more information on the Molecular Libraries RFA:
DHHS and NIH are Equal Opportunity Employers
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